Publications (2016 - )
2022
Paranjapye, A., Leir, S-H., Huang, F., Kerschner, J.L., Harris, A. (2022) Cell function and identity revealed by comparative scRNA-seq analysis in human nasal, bronchial and epididymis epithelia. Eur. J. Cell Biol. 101(3):151231. doi: 10.1016/j.ejcb.2022.151231. Epub 2022 May 18.PMID: 35597096
Yin, S., NandyMazumdar, M., Paranjapye, A., Harris, A. (2022) Cross-talk between enhancers, structural elements and activating transcription factors maintains the 3D architecture and expression of the CFTR gene. Genomics 114(3):110350. doi: 10.1016/j.ygeno.2022.110350.
Paranjapye, A., NandyMazumdar, M., Leir, S-H., Harris, A. (2022) Krüppel-Like Factor 5 regulates CFTR expression by maintaining locus architecture. J Mol Biol. 434(10): 167561. doi: 10.1016/j.jmb.2022.167561.
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Van Wettere, A.J., Leir, S-H., Cotton, C.U., Regouski, M., Viotti Perisse, I; Kerschner, J.L., Paranjapye, A., Fan, Z., Liu, Y., Schacht, M., White, K., Polejaeva, I.A*, Harris, A*. Early developmental phenotypes in the cystic fibrosis sheep model. FASEB Bioadvances: In Press.
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2021
Browne, J.A., NandyMazumdar, M., Paranjapye, A., Leir, S-H., Harris, A. (2020) The Bromodomain Containing 8 (BRD8) Transcriptional Network in Human Lung Epithelial Cells. Mol. Cell. Endocrin. Jan 18:111169. doi: 10.1016/j.mce.2021.111169.
Paranjapye, A., NandyMazumdar, M., Browne, J.A., Leir, S-H., Harris, A. (2021) Krüppel-Like Factor 5 regulates wound repair and the innate immune response in airway epithelial cells. Journal of Biological Chemistry. Aug;297(2):100932. doi: 10.1016/j.jbc.2021.100932. Epub 2021 Jul 1.
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Viotti Perisse, I; Fan, Z., Van Wettere, A.J., Liu, Y., Leir, S-H., Keim, J., Regouski, M., Wilson, M.D., Cholewa, K.M., Mansbach, S.N., Kelley, T.J., Wang, Z., Harris, A*., White, K., Polejaeva, I.A*. (2021) Generation of F508del and G542X Sheep Models of Cystic Fibrosis, which show a cellular response to human therapeutic drugs. FASEB BioAdvances. In Press.
Harris, A. (2021) Human Molecular Genetics and the long road to treating cystic fibrosis. Human Molecular Genetics In press.
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2020
Leir, S-H., Yin. S., Xia, S., Ahmadi, S., Bear. C., Harris, A. (2020) An organoid model of the human epididymis epithelium to assay how loss of CFTR impairs fertility. Cell and Tissue Research: Epub May 6th PMID: 32377875
Kerschner, J.L., Paranjapye, A., Leir, S-H., Yin, S., Skander, D., Bebek, G., Harris, A. (2020) A functional genomics approach to investigate the differentiation of iPSCs into lung epithelium at air-liquid interface. JCMM. 24(17):9853-70. doi: 10.1111/jcmm.15568
Yin, S., Kerschner, J.L., Ray., G, Hao, S., Perez, A., Drumm, M., Leir, S-H., Longworth, M., Harris, A. (2020) Functional genomics of human colon organoids. Physiological Genomics: 52(6):234-244. doi: 10.1152/physiolgenomics.00113.2019
Suzuki, S., Crane, A.M., Anirudhan, V., Matthias, N., Barillà, C., Randell, S.H., Rab, A., Sorscher, E.J., Kerschner, J.L., Yin, S., Harris, A., Mendel, M., Conway, A., Davis, B.R. (2020) Highly Efficient Gene Editing of Cystic Fibrosis Patient-derived Airway Basal Cells Results in Functional CFTR Correction. Molecular Therapy: 28(7):1684-1695. doi: 10.1016/j.ymthe.2020.04.021
Leir, S-H., Yin, S., Kerschner, J.L., Cosme, W., Harris, A. (2020) An atlas of human proximal epididymis reveals cell-specific functions and distinct roles for CFTR. Life Science Alliance 3(11):e202000744. doi: 10.26508/lsa.202000744.
Kerschner, J.L., Paranjapye, A., NandyMazumdar, M., Yin, S., Leir, S-H., Harris, A. (2020) OTX2 regulates CFTR expression during endoderm differentiation and occupies 3’ cis-regulatory elements. Dev. Dynamics. In Press.
2019
Kerschner J.L., Paranjapye, A., Cosme, W., Ferec, C., Nakakuki, M., Ishiguro, H., Rommens, J., Harris., A (2019) Sequencing of 460kb encompassing the CFTR locus in 80 CF patients with undefined mutations. J Mol Diagnostics. 21:70-80. Epub 2018 Oct 5.
Gawenis, L.R., Hodges, C.A,. McHugh, D.R., Valerio, D.M., Miron, A., Cotton, C.U., Liu, J., Walker, N.M., Strubberg, A.M., Gillen, A.E., Mutolo, M.J, Kotzamanis, G., Bosch, J., Harris, A., Drumm, M.L., Clarke, L.L. (2019) A BAC Transgenic Mouse Expressing Human CFTR under Control of Its Regulatory Elements Rescues Cftr Knockout Mice. Science Reports. 14;9(1):11828.
Swahn, H., Ebron J.S., Lamar, K-M., Yin, S., Kerschner, J.L., NandyMazumdar, M., Coppola, C., Mendenhall, E.M., Leir, S-H., Harris, A. (2019). Coordinate regulation of ELF5 and EHF at the chr11p13 CF modifier region. J Cell Mol Med. 2019 23 (11):7726-7740.
NandyMazumdar, M., Yin, S., Paranjapye, A., Kerschner, J.L., Swahn, H., Ge, A., Leir, S-H., Harris, A. (2019) Looping of upstream cis-regulatory elements is required for CFTR expression in human airway epithelial cells. Nucleic Acids Research: 48:3513-3524. Epub: Feb 25th 2020.
Paranjapye, A., Mutolo, M.J., Ebron J.S., Leir, S-H., Harris, A. (2019) FOXA1 coordinates barrier function in the human airway epithelium. American Journal of Physiology: Lung. 319:L126-L136. doi: 10.1152/ajplung.00023.2020.
2018
Strug, L. J., Stephenson, A. L., Panjwani, N., & Harris, A. (2018). Recent advances in developing therapeutics for cystic fibrosis. Human Molecular Genetics, 27(R2), R173-R186. (Invited) doi:10.1093/hmg/ddy188
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Fan, Z., Viotti Perisse, I; Cotton, C.U., Regouski, M., Meng, Q., Domb, C., Van Wettere, A.J., Wang, Z., Harris, A., White, K., Polejaeva, I.A. (2018) A Sheep Model of Cystic Fibrosis Generated byCRISPR/Cas9 Disruption of the CFTR Gene. JCI Insight EPub Oct 4.
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Browne, J. A., Leir, S. H., Eggener, S. E., & Harris, A. (2018). Region-specific microRNA signatures in the human epididymis. Asian journal of andrology.
Yang, R., Browne, J. A., Eggener, S. E., Leir, S. H., & Harris, A. (2018). A novel transcriptional network for the Androgen Receptor in human epididymis epithelial cells. MHR: Basic science of reproductive medicine. doi: 10.1093/molehr/gay029
Browne, J. A., Leir, S-H., Eggener S.E., Harris A. (2018) Region-specific innate antiviral responses of the human epididymis. Molecular and Cellular Endocrinology. pii: S0303-7207(18)30004-2. Epub 2018 Jan 13. PMID: 29339104
Gillen, A. E., Yang, R., Cotton, C. U., Perez, A., Randell, S. H., Leir, S. H., & Harris, A. (2018). Molecular characterization of gene regulatory networks in primary human tracheal and bronchial epithelial cells. Journal of Cystic Fibrosis.
Mutolo, M.J., Leir, S-H., Fossum S.L., Browne, J.A., Harris, A. (2018) A transcription factor network represses CFTR gene expression in airway epithelial cells. Biochemical Journal, 475:1323-1334
2017
Stolzenburg, L. R., & Harris, A. (2017) Microvesicle-mediated delivery of miR-1343: impact on markers of fibrosis. Cell and tissue research, 1-14. Epub 2017 Oct 11. PMID: 29022142
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Stolzenburg, L.R., Yang, R., Kerschner, J.L., Fossum, S.L., Xu, M., Hoffman, A., Ghosh, S., Lamar, K-M., Wachtel, S., Leir, S-H., Harris, A. (2017) Regulatory dynamics of 11p13 suggest a role for EHF in modifying CF lung disease severity. Nucleic Acids Research. 45:8773-8784. Epub 2017 May 26. PMCID: PMC5587731
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Fossum, S.L., Mutolo, M.J., Tugores, A., Ghosh, S., Randell, SH., Jones, L.C., Leir, S-H., Harris, A. (2017) Ets Homologous Factor (EHF) has critical roles in epithelial dysfunction in airway disease. J. Biol. Chem. 292:10938-10949. Epub 2017 May 1. PMCID: PMC5491778
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Stolzenburg, L. R., & Harris, A. (2017). The role of microRNAs in chronic respiratory disease: recent insights. Biological chemistry. PMID: 29148977
2016
Browne, J.A., Yang, R., Leir, S-H., Eggener, S.E., Harris, A., (2016) HNF1 regulates critical processes in the human epididymis epithelium. Molecular and Cellular Endocrinology. 425:94-102. Epub 2016 Jan 22. PMCID: PMC4799753
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Browne, J.A., Yang, R., Leir, S-H., Eggener, S.E., Harris, A., (2015) Expression profiles of human epididymis epithelial cells reveal the functional diversity of caput, corpus and cauda regions. Mol. Hum. Reprod. 22:69-82. Epub 2015 Nov 26. PMCID: PMC4733224
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Yang, R., Kerschner, J.L., Harris, A. (2016) Hepatocyte nuclear factor 1 coordinates multiple processes in a model of intestinal epithelial cell function. Biochim Biophys Acta. 1859(4):591-598. Epub 2016 Feb 6. PMCID: PMC4818657
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Yang, R., Kerschner, J.L., Gosalia, N., Neems, D., Gorsic, L.K., Safi, A., Crawford, G.E., Kosak, S.T., Leir, S-H., Harris, A. (2016) Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus. Nucleic Acids Res. 44(7):3082-94. Epub 2015 Dec 15. PMCID: PMC4838340
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Stolzenburg, L.R., Wachtel, S., Dang, H., Harris, A. (2016) microRNA-1343 attenuates pathways of fibrosis by targeting the TGF-β receptors. Biochemical Journal. 473(3):245-56. Epub 2015 Nov 5. PMCID: PMC4867233
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Gosalia, N., Harris, A. (2015) Chromatin Dynamics in the Regulation of CFTR Expression. Genes (Basel). 2015 Jul 13;6(3):543-58. PMCID: PMC4584316